Avhandlingar / Theses
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Studies on the modulation of gene expression via 3´UTR editing to model and treat neurological disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)It is increasingly clear that gene expression levels play a critical role in human health. For example, genome-wide association studies (GWAS) reveal that at least 93% of diseaseassociated changes are in non-coding ... -
The role of autophagy in Aβ and tau metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)Alzheimer’s disease (AD) is characterized by amyloid plaques composed of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs) containing hyperphosphorylated and misfolded tau proteins. Aβ is generated ... -
Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ... -
Enhancing hospital care coordination : a resilience-centric approach to challenges and potential strategies
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-05-14)Background: The realms of patient flow management and care coordination, both aiming to optimize care delivery, are governed by distinct operational logics. Patient flow management is primarily a strategic tool concerned ... -
Clinical and radiological features of thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-14)Background: The pathologies of the aorta constitute a group of severe diseases often managed by means of a single variable, the maximum aortic diameter. This variable is insufficient, and the aim of this work is to ... -
Decoding the symphony : illuminating the mammalian mitochondrial RNA binding proteome with a novel interactome approach
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-14)Mitochondria, colloquially known as the "powerhouses of the cell" are crucial for generating cellular energy through a process known as oxidative phosphorylation (OXPHOS). These minute but mighty organelles are distinct ... -
Biomarkers in hepatocellular carcinoma
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-13)Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Globally in 2020, liver cancer were the seventh most common cancer form and the second most common form of cancer related death. Early HCCs are often ... -
Aspects on diabetes and diet with special focus on carbohydrates : epidemiological and clinical studies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-13)Carbohydrate intake affects blood glucose levels more than any other dietary factor, providing a conceptually promising area of research in the prevention and management of diabetes. Intake of fruit and vegetables, a ... -
Evaluation of new and current preventive strategies for cervical and vaginal cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-05-08)This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ... -
Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Major lower extremity amputations : outcomes, complications, and patient perspectives
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-07)An amputation is considered to be one of the oldest surgical procedures; yet, despite advancements in medical care, it continues to be associated with high rates of complications and postoperative mortality. This thesis ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ... -
Pyrocarbon in shoulder hemi arthroplasty
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Pyrolytic carbon, or pyrocarbon (PyC), has biocompatibility, a low friction coefficient and good wear resistance, making it a material of great potential for use in orthopaedics. PyC shoulder implants have shown promising ... -
Diet, genetic susceptibility, latent autoimmune diabetes in adults, type 1 and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-03)Diabetes is one of the most common chronic diseases, yet our understanding of modifiable risk factors remains incomplete. This project aimed to elucidate the role of diet in the risk of latent autoimmune diabetes in adults ... -
Hepatic diseases at the molecular level : identifying novel targets and biomarkers through transcriptomics
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-05-03)In the last few decades, the prevalence of obesity and metabolic diseases have dramatically increased and pose a major threat to global healthcare systems. The chronic excess of carbohydrates and fat is a risk factor for ... -
Mortality prediction and equity in emergency care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Introduction: Emergency departments (EDs) face crowding and long patient waiting times due to resource-demand imbalances. Waiting exposes patients to sufferings and risks, such as pain, anxiety, permanent organ damage, or ... -
Impact of non-health sector determinants on child health the role of the Sustainable Development Goals : models, practices and perceptions in Cambodia and globally
(Inst för global folkhälsa / Dept of Global Public Health, 2024-05-02)Background. Child health has improved significantly over the last decades in Cambodia and globally. With the global adoption of the Sustainable Development Goals (SDGs) in 2015, a broad set of interlinked global goals to ... -
Surgical treatment of lung cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-02)Background: Surgery is a central part in the treatment of lung cancer. There have been recent advances in minimal invasive and lung sparing surgical techniques, but evidence regarding safety and implementability is not ...