Volume 34, No 5, May 2024

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

The image illustrates a Chinese historical story, depicting Taigong Jiang fishing with his hook, reminiscent of the innovative proximity labeling tool, PhastID. PhastID identifies ATP6AP1, an unconventional GEF of Rheb. The C-tail at the end of ATP6AP1 can be used as a switch for Rheb to regulate the activation of mTORC1 signaling. Just as the two different states of the fish in the image, activating Rheb or not has distinct impacts on cellular functions. See page 355–369 by Ran Feng et al. for details.

Advanced Online Publication: 8 May 2024

RESEARCH HIGHLIGHTS

ILC2s govern sex-differential immunity in skin

Network-level time computations in the suprachiasmatic nucleus

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Current Issue: Vol.34 (May 2024)

RESEARCH HIGHLIGHTS

Treating insomnia with 40 Hz light flicker
Amino acid availability governs mTOR ubiquitination
Chromatin compartments at DNA double-stranded breaks
T follicular regulatory cells keep B cell-directed autoreactivity in check
A perfect storm: sleep loss causes systemic inflammation and death
The new horizon of plant auxin signaling via cell-surface co-receptors

ORIGINAL ARTICLES

Multiple cancer cell types release LIF and Gal3 to hijack neural signals
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

LETTERS TO THE EDITOR

CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization
An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies

CORRIGENDA

Publisher Correction: The new horizon of plant auxin signaling via cell-surface co-receptors